The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase. Takle AK, Bamford MJ, Davies S, Davis RP, Dean DK, Gaiba A, Irving EA, King FD, Naylor A, Parr CA, Ray AM, Reith AD, Smith BB, Staton PC, Steadman JG, Stean TO, Wilson DM.
Showing posts with label B-Raf. Show all posts
Showing posts with label B-Raf. Show all posts
Saturday, August 23, 2008
Thursday, August 21, 2008
PDB Update 08/21/08
3D4Q
Pyrazole-based inhibitors of B-Raf kinase
Resolution: 2.80 Å
3DB6
Crystal structure of an activated (Thr->Asp) Polo-like kinase 1 (Plk1) catalytic domain in complex with Compound 902
Resolution: 2.85 Å
3DCV
Crystal structure of human Pim1 kinase complexed with 4-(4-hydroxy-3-methyl-phenyl)-6-phenylpyrimidin-2(1H)-one
Resolution: 2.70 Å
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